CYP1A2 ELISA Kit for Human(Homo sapiens) | EIAab.comCYP1A2 ELISA Kit for Human(Homo sapiens)

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CYP1A2 (Gene name),

Cytochrome P450 1A2 (Protein name ), CP1A2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYP1A2;

Protein name:

Cytochrome P450 1A2;

Alternative:

Cytochrome P(3)450;CYPIA2;Cytochrome P450-P3;Cytochrome P450 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

515

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

515:

HARCEHVQAR | RFSIN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P05177

STRING:

9606.ENSP00000342007

MIM:

108330

Pfam:

PF00067

String:

P05177

UniGene:

Hs.1361

KEGG:

hsa:1544

Uniprot:

P05177

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ELISA Kit for Human Cytochrome P450 1A2

Cat.:

E10137h

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96T

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ELISA Kit for Human Cytochrome P450 1A2

Cat.:

E10137m

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Packing:

96T

ELISA Kit for Human Cytochrome P450 1A2

Cat.:

E10137r

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96T

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ELISA Kit for Human Cytochrome P450 1A2

Cat.:

E10137c

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96T

ELISA Kit for Human Cytochrome P450 1A2

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ELISA Kit for Human Cytochrome P450 1A2

Cat.:

E10137d

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Packing:

96T

CLIA Kit for Human Cytochrome P450 1A2

Cat.:

U10137h

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96T

CLIA Kit for Human Cytochrome P450 1A2

Cat.:

U10137r

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96T

CLIA Kit for Human Cytochrome P450 1A2

Cat.:

U10137d

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96T

CLIA Kit for Human Cytochrome P450 1A2

Cat.:

U10137c

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Packing:

96T

CLIA Kit for Human Cytochrome P450 1A2

Cat.:

U10137m

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MSDS:

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Packing:

96T

CLIA Kit for Human Cytochrome P450 1A2

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Polyclonal Antibody for Human Cytochrome P450 1A2

Cat.:

P10137Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 1A2

Cat.:

P10137Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 1A2

Cat.:

P10137Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 1A2

Protein for Human Cytochrome P450 1A2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Human P3(450): cDNA and complete amino acid sequence."
Jaiswal A.K. , Nebert D.W. , Gonzalez F.J.
Nucleic Acids Res.14:6773-6774(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA."
Quattrochi L.C. , Pendurthi U.R. , Okino S.T. , Potenza C. , Tukey R.H.
Proc. Natl. Acad. Sci. U.S.A.83:6731-6735(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
3.

"Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression."
Ikeya K. , Jaiswal A.K. , Owens R.A. , Jones J.E. , Nebert D.W. , Kimura S.
Mol. Endocrinol.3:1399-1408(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15."
Jaiswal A.K. , Nebert D.W. , McBride O.W. , Gonzalez F.J.
J. Exp. Pathol.3:1-17(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
5.

"Sequence of a new human cytochrome P450-1A2 cDNA."
Zhuge J. , Qian Y. , Xie H. , Yu Y.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT VAL-314
tissue: Liver.
6.

"Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
Corchero J. , Pimprale S. , Kimura S. , Gonzalez F.J.
Pharmacogenetics11:1-6(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

NIEHS SNPs program
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-73; ASN-104; PHE-111; VAL-205; TRP-281 AND ILE-438
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
9.

"Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat."
Wrighton S.A. , Campanile C. , Thomas P.E. , Maines S.L. , Watkins P.B. , Parker G. , Mendez-Picon G. , Haniu M. , Shively J.E. , Levin W. , Guzelian P.S.
Mol. Pharmacol.29:405-410(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-19
10.

"Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
Quattrochi L.C. , Okino S.T. , Pendurthi U.R. , Tukey R.H.
DNA4:395-400(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-485
tissue: Liver.
11.

"Functional characterization of four allelic variants of human cytochrome P450 1A2."
Zhou H. , Josephy P.D. , Kim D. , Guengerich F.P.
Arch. Biochem. Biophys.422:23-30(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;CHARACTERIZATION OF VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431
12.

"Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2."
Sansen S. , Yano J.K. , Reynald R.L. , Schoch G.A. , Griffin K.J. , Stout C.D. , Johnson E.F.
J. Biol. Chem.282:14348-14355(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 27-515 IN COMPLEX WITH THE INHIBITOR ALPHA-NAPHTHOFLAVONE AND HEME
13.

"Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese."
Huang J.D. , Guo W.C. , Lai M.D. , Guo Y.L. , Lambert G.H.
Drug Metab. Dispos.27:98-101(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-21
14.

"Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population."
Chevalier D. , Cauffiez C. , Allorge D. , Lo-Guidice J.-M. , Lhermitte M. , Lafitte J.-J. , Broly F.
Hum. Mutat.17:355-356(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431
15.

"Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes."
Murayama N. , Soyama A. , Saito Y. , Nakajima Y. , Komamura K. , Ueno K. , Kamakura S. , Kitakaze M. , Kimura H. , Goto Y. , Saitoh O. , Katoh M. , Ohnuma T. , Kawai M. , Sugai K. , Ohtsuki T. , Suzuki C. , Minami N. , more...
J. Pharmacol. Exp. Ther.308:300-306(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-83; GLN-168; LEU-186; CYS-212; SER-299 AND ILE-438
16.

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-18; ARG-298; VAL-314 AND TRP-431
17.

"Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population."
Soyama A. , Saito Y. , Hanioka N. , Maekawa K. , Komamura K. , Kamakura S. , Kitakaze M. , Tomoike H. , Ueno K. , Goto Y. , Kimura H. , Katoh M. , Sugai K. , Saitoh O. , Kawai M. , Ohnuma T. , Ohtsuki T. , Suzuki C. , more...
Drug Metab. Pharmacokinet.20:24-33(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-42; GLN-377 AND HIS-456
18.

"Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
Jiang Z. , Dalton T.P. , Jin L. , Wang B. , Tsuneoka Y. , Shertzer H.G. , Deka R. , Nebert D.W.
Hum. Mutat.25:196-206(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-18
19.

"Coffee, CYP1A2 genotype, and risk of myocardial infarction."
Cornelis M.C. , El-Sohemy A. , Kabagambe E.K. , Campos H.
JAMA295:1135-1141(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECT OF CAFFEINE METABOLISM ON RISKS OF MYOCARDIAL INFARCTION

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